This will be the first El Clasico without both Lionel Messi and Cristiano Ronaldo since November 2005.
FC Barcelona are in debt and without form on the pitch with their manager, Ronald Koeman, under consistent pressure, though that is to be expected.
The Catalans are eighth on the La Liga table after eight games; having scored 14 goals and conceded eight though they have lost just once the same as Real Madrid.
Can Koeman engineer a win that will guarantee he continues as a manager or will Ancelotti’s team apply the stab that will send him out of the Nou Camp?
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Kick-off is 3.15 pm